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  • Collagen II Antibodies

Invitrogen

Collagen II Polyclonal Antibody

View all (31) Collagen II antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite Collagen II Polyclonal Antibody

  • Antibody Testing Data (2)
Collagen II Antibody in Immunohistochemistry (Frozen) (IHC (F))
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Collagen II Antibody in Immunohistochemistry (Frozen) (IHC (F))
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FIGURE: 1 / 2

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Collagen II Antibody (PA5-79057) in IHC (F)

Immunohistochemistry analysis of Collagen II on frozen rat Trachea tissue. Sample was incubated with Collagen II polyclonal antibody (Product# PA5-79057). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Collagen II Antibody in Immunohistochemistry (Frozen) (IHC (F))
Collagen II Antibody in Western Blot (WB)
Collagen II Polyclonal Antibody

Product Details

PA5-79057

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Collagen II1222-1241aa AFAGLGQREKGPDPMQYMRA).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746173

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Trachea Tissue.

Target Information

COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-1 type II collagen; CGA; chondrocalcin; Collagen 2; Collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; disproportionate micromelia; MGC131516; Procollagen II alpha 1; procollagen, type II, alpha 1

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Gene Aliases: CG2A1A; Col2; Col2a; Col2a-1; Col2a1; COLLII; Del1; Dmm; Lpk; M100856; Rgsc856

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UniProt ID: (Rat) P05539, (Mouse) P28481

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Entrez Gene ID: (Rat) 25412, (Mouse) 12824

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Function(s)
extracellular matrix structural constituent identical protein binding metal ion binding platelet-derived growth factor binding
Process(es)
skeletal system development cartilage condensation tissue homeostasis endochondral ossification chondrocyte differentiation heart morphogenesis growth plate cartilage development proteoglycan metabolic process central nervous system development visual perception sensory perception of sound response to mechanical stimulus response to X-ray regulation of gene expression collagen fibril organization notochord development limb morphogenesis inner ear morphogenesis skeletal system morphogenesis inner ear development cartilage development palate development limb bud formation embryonic skeletal joint morphogenesis bone development cartilage development involved in endochondral bone morphogenesis cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to nicotine cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus cellular response to peptide hormone stimulus otic vesicle development cellular response to BMP stimulus response to fibroblast growth factor negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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