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Proteintech
Centromere protein R Polyclonal Antibody
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Product Details
10743-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MPVKRSLKL DGLLEENSFD PSKITRKKSV ITYSPTTGTC QMSLFASPTS SEEQKHRNGL SNEKRKKLNH PSLTESKEST TKDNDEFMML LSKVEKLSEE IMEIMQNLSS IQALEGSREL ENLIGISCAS HFLKREMQKT KELMTKVNKQ KLFEKSTGLP HKASRHLDSY EFLKAILN (1-177 aa encoded by BC009929)
Target Information
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta 3 endonexin; Beta-3-endonexin; beta3-endonexin; CENP-R; Centromere protein R; integrin beta 3 binding protein (beta3-endonexin); Integrin beta-3-binding protein; Nuclear receptor-interacting factor 3
Gene Aliases: CENP-R; CENPR; HSU37139; ITGB3BP; NRIF3; TAP20
UniProt ID: (Human) Q13352
Entrez Gene ID: (Human) 23421
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