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Invitrogen
Cardiac Troponin I Polyclonal Antibody
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FIGURE: 1 / 3
Cardiac Troponin I Antibody (PA5-85358) in ICC/IF
Product Details
PA5-85358
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Dog (97%), Cat (97%), Pig (95%), Bovine (97%).
Positive Control: 293T, Raji, mouse heart.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); MGC116817; Tpn1; troponin I type 3 (cardiac); Troponin I, cardiac muscle
Gene Aliases: CMD1FF; CMD2A; CMH7; cTnI; RCM1; Tn1; TNNC1; TNNI3
UniProt ID: (Human) P19429, (Mouse) P48787
Entrez Gene ID: (Human) 7137, (Pig) 100049696, (Mouse) 21954
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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