Rockland

Calreticulin precursor Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Calreticulin precursor Polyclonal Antibody

Product Details

600-401-J41

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (IHC)

Assay-dependent
-

ELISA (ELISA)

1: 10,000
-

Immunoprecipitation (IP)

0.2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Calreticulin precursor affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of human calreticulin precursor protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.42 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 50% glycerol

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

A BLAST analysis was used to suggest cross-reactivity with human, mouse, rat, primate, and chicken based on 100% sequence homology. Cross-reactivity with Calreticulin precursor from other sources has not been determined.

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen RO; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)

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Gene Aliases: CALR; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA

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UniProt ID: (Human) P27797

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Entrez Gene ID: (Human) 811

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Function(s)
complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding poly(A) RNA binding androgen receptor binding unfolded protein binding chaperone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter antigen processing and presentation of peptide antigen via MHC class I peptide antigen assembly with MHC class I protein complex regulation of transcription, DNA-templated protein folding protein export from nucleus cellular calcium ion homeostasis receptor-mediated endocytosis cell cycle arrest spermatogenesis positive regulation of cell proliferation positive regulation of gene expression negative regulation of translation protein maturation by protein folding cortical actin cytoskeleton organization response to estradiol negative regulation of intracellular steroid hormone receptor signaling pathway response to testosterone protein localization to nucleus protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response regulation of meiotic nuclear division response to drug glucocorticoid receptor signaling pathway regulation of apoptotic process negative regulation of neuron differentiation positive regulation of DNA replication positive regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization sequestering of calcium ion cardiac muscle cell differentiation chaperone-mediated protein folding cellular response to lithium ion cellular senescence positive regulation of substrate adhesion-dependent cell spreading positive regulation of dendritic cell chemotaxis
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