Invitrogen

Calreticulin Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Calreticulin Polyclonal Antibody

Product Details

PA5-19854

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to aa(E-E-E-D-V-P-G-Q-A-K-D-E-L-C)of human Calreticulin, conjugated to KLH (aa 405-417).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11008025

Product Specific Information

PA5-19854 targets Calreticulin in indirect ELISA, Western Blot applications and shows reactivity with Human samples.

The PA5-19854 immunogen is synthetic peptide corresponding to aa(E-E-E-D-V-P-G-Q-A-K-D-E-L-C)of human Calreticulin, conjugated to KLH.

Target Information

Calr or Calreticulin is a calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. Calr, a lectin, interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Calr also interacts with with the DNA-binding domain of NR3C1 and mediates its nuclear export. It may also be involved in maternal gene expression regulation and oocyte maturation via the regulation of calcium homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Autoantigen RO; Calregulin; Calreticulin; CRP55; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; Ro/SS-A Antigen; Sicca syndrome antigen A (autoantigen Ro; calreticulin)

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Gene Aliases: CALR; cC1qR; CRT; CRTC; HEL-S-99n; RO; SSA

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UniProt ID: (Human) P27797

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Entrez Gene ID: (Human) 811

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Function(s)
complement component C1q binding glycoprotein binding DNA binding mRNA binding integrin binding iron ion binding calcium ion binding protein binding zinc ion binding carbohydrate binding ubiquitin protein ligase binding peptide binding hormone binding protein binding involved in protein folding poly(A) RNA binding androgen receptor binding unfolded protein binding chaperone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter antigen processing and presentation of peptide antigen via MHC class I peptide antigen assembly with MHC class I protein complex regulation of transcription, DNA-templated protein folding protein export from nucleus cellular calcium ion homeostasis receptor-mediated endocytosis cell cycle arrest spermatogenesis positive regulation of cell proliferation positive regulation of gene expression negative regulation of translation protein maturation by protein folding cortical actin cytoskeleton organization response to estradiol negative regulation of intracellular steroid hormone receptor signaling pathway response to testosterone protein localization to nucleus protein folding in endoplasmic reticulum ATF6-mediated unfolded protein response regulation of meiotic nuclear division response to drug glucocorticoid receptor signaling pathway regulation of apoptotic process negative regulation of neuron differentiation positive regulation of DNA replication positive regulation of cell cycle negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway positive regulation of phagocytosis protein stabilization sequestering of calcium ion cardiac muscle cell differentiation chaperone-mediated protein folding cellular response to lithium ion cellular senescence positive regulation of substrate adhesion-dependent cell spreading positive regulation of dendritic cell chemotaxis
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