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  • Calcitonin Receptor Antibodies

Alomone Labs, LTD

Calcitonin Receptor (extracellular) Polyclonal Antibody

View all (15) Calcitonin Receptor antibodies

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Datasheet
Protocols
Questions & Answers

Cite Calcitonin Receptor (extracellular) Polyclonal Antibody

  • Antibody Testing Data (2)
Calcitonin Receptor (extracellular) Antibody in Immunocytochemistry (ICC/IF)
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Calcitonin Receptor (extracellular) Antibody in Immunocytochemistry (ICC/IF)
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Calcitonin Receptor (extracellular) Antibody (ACR-053-200UL) in ICC/IF

Expression of CALCR in rat PC12 cells - Cell surface detection of CALCR in intact living rat pheochromocytoma (PC12) cells. A, C. Extracellular staining of cells using Anti-Calcitonin Receptor (extracellular) Antibody , (#ACR-053), (1:50). B, D. Merged images of A and C, each with its respective live view of the cells. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Calcitonin Receptor (extracellular) Antibody in Immunocytochemistry (ICC/IF)
Calcitonin Receptor (extracellular) Antibody in Western Blot (WB)
Calcitonin Receptor (extracellular) Polyclonal Antibody

Product Details

ACR-053-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunocytochemistry (ICC/IF)

1:50
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)HLVEVVPNGDLVRRD, corresponding to amino acid residues 201-215 of rat CALCR, 1st extracellular loop
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C1A/C1B; Calcitonin receptor; COPT1; CT receptor; CT-R; hCTR1

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Gene Aliases: Calcr; Clr

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UniProt ID: (Rat) P32214, (Mouse) Q60755

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Entrez Gene ID: (Rat) 116506, (Mouse) 12311

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Function(s)
receptor activity calcitonin receptor activity protein transporter activity calcitonin binding signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity
Process(es)
G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration protein transport negative regulation of ossification osteoclast differentiation positive regulation of cAMP biosynthetic process receptor internalization regulation of mRNA stability regulation of bone resorption positive regulation of adenylate cyclase activity response to glucocorticoid protein localization to plasma membrane signal transduction cell surface receptor signaling pathway
It has to be done as per old AB suggested Products section.
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