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  • Calcitonin Antibodies

Invitrogen

Calcitonin Recombinant Rabbit Monoclonal Antibody (PD00-46)

View all (49) Calcitonin antibodies

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Datasheet
Protocols
Questions & Answers

Cite Calcitonin Recombinant Rabbit Monoclonal Antibody (PD00-46)

  • Antibody Testing Data (1)
Calcitonin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Calcitonin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Calcitonin Antibody (MA5-50711) in IHC (P)

Immunohistochemistry of Calcitonin in paraffin-embedded human medullary thyroid carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with Calcitonin recombinant monoclonal antibody (Product # MA5-50711) with a dilution... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Calcitonin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Calcitonin Recombinant Rabbit Monoclonal Antibody (PD00-46)

Product Details

MA5-50711

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:5,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

PD00-46

Immunogen

Synthetic peptide within human Calcitonin aa 85-116/141.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093950

Product Specific Information

Positive control: Human medullary thyroid carcinoma tissue.

Predicted band size: 15.5 kDa

Subcellular Location: Secreted.

Target Information

Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha CGRP; Alpha type CGRP; Alpha-type CGRP; Calcitonin; calcitonin 1; calcitonin gene related peptide 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; katacalcin (KC)

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Gene Aliases: CALC1; CALCA; CGRP; CGRP-I; CGRP1; CT; KC; PCT

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UniProt ID: (Human) P01258

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Entrez Gene ID: (Human) 796

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Function(s)
hormone activity protein binding calcitonin receptor binding identical protein binding
Process(es)
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate monocyte chemotaxis inflammatory response adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway embryo implantation aging feeding behavior response to heat negative regulation of ossification negative regulation of neurological system process activation of protein kinase activity cellular protein metabolic process positive regulation of adenylate cyclase activity positive regulation of ossification negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus
It has to be done as per old AB suggested Products section.
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