Fabgennix

Calcitonin Polyclonal Antibody, Biotin

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Calcitonin Polyclonal Antibody, Biotin

Product Details

CLTN-112-BIOTIN

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 43-93 on human Calcitonin protein.
View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha CGRP; Alpha type CGRP; Alpha-type CGRP; Calcitonin; calcitonin 1; calcitonin gene related peptide 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; katacalcin (KC)

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Gene Aliases: CA; Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-1; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6

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UniProt ID: (Human) P06881, (Rat) P01257, (Mouse) Q99JA0

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Entrez Gene ID: (Human) 796, (Rat) 24241, (Mouse) 12310

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Function(s)
hormone activity protein binding calcitonin receptor binding identical protein binding receptor binding neuropeptide hormone activity protein complex binding
Process(es)
endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis inflammatory response leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway neuromuscular junction development embryo implantation aging feeding behavior regulation of heart contraction regulation of blood pressure response to heat negative regulation of calcium ion transport into cytosol negative regulation of ossification positive regulation of cAMP biosynthetic process receptor internalization negative regulation of neurological system process activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation positive regulation of adenylate cyclase activity negative regulation of blood pressure positive regulation of ossification negative regulation of bone resorption positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus cellular protein metabolic process sperm capacitation mitophagy in response to mitochondrial depolarization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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