Invitrogen

CTGF Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
CTGF Polyclonal Antibody

Product Details

PA5-14884

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 315-349 amino acids from the C-terminal region of human CTGF
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Size-exclusion - Dialysis, Ammonium sulfate precipitation

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2087349

Product Specific Information

This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.

Target Information

Connective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. CTGF plays important roles in the proliferation and differentiation of chondrocytes, induces angiogenesis, and promotes cell adhesion in fibroblasts, endothelial, and epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2-Nov; CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; H-CTGF; Hypertrophic chondrocyte-specific protein 24; IBP-8; IGF-binding protein 8; IGFBP-8; Insulin-like growth factor-binding protein 8; MGC102839

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Gene Aliases: CCN2; CTGF; HCS24; IGFBP8; NOV2

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UniProt ID: (Human) P29279

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Entrez Gene ID: (Human) 1490

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Function(s)
fibronectin binding integrin binding protein binding insulin-like growth factor binding protein C-terminus binding growth factor activity heparin binding
Process(es)
cartilage condensation ossification angiogenesis regulation of cell growth tissue homeostasis transcription initiation from RNA polymerase II promoter cell adhesion cell-matrix adhesion integrin-mediated signaling pathway cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway epidermis development response to wounding response to glucose organ senescence positive regulation of gene expression negative regulation of gene expression cell migration cell differentiation lung development regulation of chondrocyte differentiation response to estradiol positive regulation of collagen biosynthetic process response to anoxia intracellular signal transduction chondrocyte proliferation response to amino acid positive regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone positive regulation of cell differentiation positive regulation of JNK cascade positive regulation of cell activation response to mineralocorticoid positive regulation of stress fiber assembly cytosolic calcium ion transport positive regulation of cardiac muscle contraction negative regulation of cell death extracellular matrix constituent secretion positive regulation of G0 to G1 transition positive regulation of ERK1 and ERK2 cascade response to fatty acid DNA biosynthetic process reactive oxygen species metabolic process
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