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Abnova
CRIM1 Monoclonal Antibody (6E4)
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Product Details
H00051232-M01
Species Reactivity
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Clone
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Conjugate
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Product Specific Information
Immunogen sequence: VCLPCDESKC EEPRNCPGSI VQGVCGCCYT CASQRNESCG GTFGIYGTCD RGLRCVIRPP LNGDSLTEYE AGVCEDENWT DDQLLGFKPC NENLIAGCNI INGKCECNTI
Target Information
CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CRIM-1; cysteine rich transmembrane BMP regulator 1 (chordin-like); Cysteine-rich motor neuron 1 protein; Cysteine-rich repeat-containing protein S52
Gene Aliases: CRIM-1; CRIM1; S52; UNQ1886/PRO4330
UniProt ID: (Human) Q9NZV1
Entrez Gene ID: (Human) 51232
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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