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COL1A1 Monoclonal Antibody (3G3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
COL1A1 Monoclonal Antibody (3G3)

Product Details

H00001277-M01J

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-Dependent
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

3G3

Immunogen

COL1A1 (NP_000079.1, 1021 a.a. approximately 1108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: EGSPGRDGSP GAKGDRGETG PAGPPGAPGA PGAPGPVGPA GKSGDRGETG PAGPAGPVGP VGARGPAGPQ GPRGDKGETG EQGDRGIK

Target Information

The protein encoded by this gene is the pro-alpha1 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-1 type 1 collagen; Alpha-1 type I collagen; alpha1(I) procollagen; COL1A; Collagen 1; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen I; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; Collagen1A1; pro-alpha-1 collagen type 1; procollagen, type I, alpha 1; Type I Collagen; type I proalpha 1; type I procollagen alpha 1 chain

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Gene Aliases: Col1a-1; COL1A1; Cola-1; Cola1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452, (Mouse) P11087

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Entrez Gene ID: (Human) 1277, (Mouse) 12842

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Function(s)
extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding
Process(es)
skeletal system development blood vessel development osteoblast differentiation intramembranous ossification endochondral ossification blood coagulation visual perception sensory perception of sound positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion protein transport platelet activation extracellular matrix organization collagen fibril organization positive regulation of cell migration collagen catabolic process response to corticosteroid response to estradiol collagen biosynthetic process protein localization to nucleus tooth mineralization response to drug response to hydrogen peroxide response to peptide hormone skin morphogenesis cellular response to fibroblast growth factor stimulus tooth eruption positive regulation of transcription, DNA-templated embryonic skeletal system development regulation of immune response leukocyte migration response to cAMP response to hyperoxia face morphogenesis bone trabecula formation cartilage development involved in endochondral bone morphogenesis protein heterotrimerization cellular response to amino acid stimulus cellular response to mechanical stimulus cellular response to retinoic acid cellular response to vitamin E cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway cellular response to fluoride wound healing skin development skeletal system morphogenesis
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