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Invitrogen
CHN2 Polyclonal Antibody
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FIGURE: 1 / 5
CHN2 Antibody (PA5-119022) in IHC (P)
Product Details
PA5-119022
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Target Information
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: beta chimerin; Beta-chimaerin; Beta-chimerin; chimerin (chimaerin) 2; OTTHUMP00000202260; Rho GTPase-activating protein 3
Gene Aliases: Arhgap3; Bch; Chn2
UniProt ID: (Rat) Q03070
Entrez Gene ID: (Rat) 84031
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