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  • CHI3L1 Antibodies

Invitrogen

CHI3L1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers

Cite CHI3L1 Polyclonal Antibody

  • Antibody Testing Data (1)
CHI3L1 Antibody in Western Blot (WB)
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CHI3L1 Antibody in Western Blot (WB)
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CHI3L1 Antibody (PA5-102703) in WB

Western blot analysis of CHI3L1 in TPH1 cell lysate (left lane: treated with the antigen-specific peptide). Samples were incubated with CHI3L1 polyclonal antibody (Product # PA5-102703). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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CHI3L1 Antibody in Western Blot (WB)
CHI3L1 Polyclonal Antibody

Product Details

PA5-102703

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CHI3L1(Accession P36222), corresponding to amino acid residues A251-D301.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2852097

Product Specific Information

Antibody detects endogenous levels of total CHI3L1.

Target Information

Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 39 kDa synovial protein; Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase 3-like 1 protein; Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39; YKL-40

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Gene Aliases: ASRT7; AW208766; Brp39; CGP-39; CHI3L1; Chil1; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40

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UniProt ID: (Human) P36222, (Rat) Q9WTV1, (Mouse) Q61362

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Entrez Gene ID: (Human) 1116, (Rat) 89824, (Mouse) 12654

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Function(s)
chitinase activity extracellular matrix structural constituent chitin binding carbohydrate binding molecular_function hydrolase activity, hydrolyzing O-glycosyl compounds
Process(es)
carbohydrate metabolic process chitin catabolic process apoptotic process inflammatory response activation of NF-kappaB-inducing kinase activity positive regulation of peptidyl-threonine phosphorylation lung development positive regulation of angiogenesis positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade interleukin-8 secretion immune response response to mechanical stimulus response to tumor necrosis factor response to interleukin-1 response to interleukin-6 cellular response to interleukin-1 cellular response to tumor necrosis factor cartilage development
It has to be done as per old AB suggested Products section.
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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