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Proteintech
CHCHD6 Polyclonal Antibody
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Product Details
20639-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MGSTESSEG RRVSFGVDEE ERVRVLQGVR LSENVVNRMK EPSSPPPAPT SSTFGLQDGN LRAPHKESTL PRSGSSGGQQ PSGMKEGVKR YEQEHAAIQD KLFQVAKRER EAATKHSKAS LPTGEGSISH EEQKSVRLAR ELESREAELR RRDTFYKEQL ERIERKNAEM YKLSSEQFHE AASKMESTIK PRRVEPVCSG LQAQILHCYR DRPHEVLLCS DLVKAYQRCV SAAHKG (1-235 aa encoded by B C006123)
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; Coiled-coil-helix cristae morphology protein 1; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; MICOS complex subunit MIC25; protein phosphatase 1, regulatory subunit 23
Gene Aliases: CHCHD6; CHCM1; MIC25; PPP1R23
UniProt ID: (Human) Q9BRQ6
Entrez Gene ID: (Human) 84303
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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