Proteintech

CDK1 Monoclonal Antibody (2A11E4)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

67575-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000
View 8 publications 8 publications

Flow Cytometry (Flow)

0.20 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

2A11E4

Immunogen

CDK1 Fusion Protein Ag29018

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ABL1; CDK1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; Cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054

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Gene Aliases: CDC2; CDC28A; Cdc2a; CDK1; CDKN1; p34; P34CDC2

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UniProt ID: (Human) P06493, (Rat) P39951, (Mouse) P11440

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Entrez Gene ID: (Human) 983, (Rat) 54237, (Mouse) 12534

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Function(s)
protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity cyclin binding Hsp70 protein binding histone kinase activity kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
mitotic cell cycle protein complex assembly protein phosphorylation apoptotic process mitotic nuclear division mitotic G2 DNA damage checkpoint cell aging response to toxic substance response to organonitrogen compound positive regulation of gene expression response to organic cyclic compound response to amine response to activity histone phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation chromosome condensation epithelial cell differentiation organ regeneration positive regulation of protein import into nucleus, translocation protein localization to kinetochore response to drug response to hydrogen peroxide negative regulation of apoptotic process response to ethanol positive regulation of DNA replication positive regulation of mitotic cell cycle response to cadmium ion response to copper ion response to axon injury cell division ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cellular response to hydrogen peroxide cell cycle phosphorylation G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle activation of MAPK activity microtubule cytoskeleton organization DNA replication DNA repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear envelope disassembly centrosome cycle pronuclear fusion regulation of Schwann cell differentiation cell migration anaphase-promoting complex-dependent catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of embryonic development negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Golgi disassembly positive regulation of protein localization to nucleus
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