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Abnova
CDH11 Monoclonal Antibody (2C67)
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Product Details
H00001009-M25
Species Reactivity
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Product Specific Information
Immunogen sequence: GWVWNQFFVI EEYTGPDPVL VGRLHSDIDS GDGNIKYILS GEGAGTIFVI DDKSGNIHAT KTLDREERAQ YTLMAQAVDR DTNRPLEPPS EFIVKVQDIN DNPPEFLHET YHANVPERSN VGTSVIQVTA SDADDPTYGN SAKLVYSILE GQPYFSVEAQ TGIIRTALPN MDREAKEEYH VVIQAKDMGG HMGGLSGTTK VMITLTDVND NPPKFPQSVY QMSVSEAAVP GEEVGRVKAK DPDIGENGLV TYNIVDGDGM ESFEITTDYE TQEGVIKLKK PVDFETKRAY SLKVEAANVH IDPKFISNGP FKDTVTVKIA VEDADEPPMF LAPSYIHEVQ ENAAAGTVVG RVHAKDPDAA NSPIRYSIDR HTDLDRFFTI NPEDGFIKTT KPLDREETAW LNITVFAAEI HNRHQEAKVP VAIRVLDVND NAPKFAAPYE GFICESDQTK PLSNQPIVTI SADDKDDTAN GPRFIFSLPP EIIHNPNFTV RDNRDNTAGV YARRGGFSRQ KQDLYLLPIV ISDGGIPPMS STNTLTIKVC GCDVNGALLS CNAEAYILN
Target Information
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. All cadherins are single-pass transmembrane proteins with a variable number of 110 amino acid extracellular cadherin (EC) domains. Classical cadherins contain five large N-terminal EC domains, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Based on amino acid alignment, classical cadherins are divided into type I and type II subgroups. Type I cadherins, including cadherins E (epithelial), N (neural), P (placental), and R (retinal) cadherin differ from type I cadherins in their specific amino acid sequences. Type II cadherins include human cadherin-5, -6, -8, -11, and -12. Type II cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin-11 (OB-Cadherin) is a marker of the loosely connected and migratory cellular elements of the mesenchyme. Strong expression of Cadherin-11 has been noted in brain, spinal cord, bone marrow and bone cells, and is regulated in human endometrial glandular epithelial and stromal cells. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. A variant Cadherin-11 gene (variant form) encodes a truncated protein with an unusual cytoplasmic domain not present in other cadherins. The variant protein is generated by alternative splicing, utilizing a 179 bp intronic sequence. Recently, Cadherin-11 mRNA and protein were found to be expressed in most invasive breast cancer cell lines tested but not in non-invasive cell lines, suggesting that Cadherin-11 may be a marker for aggressive, invasive tumor subsets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cadherin; cadherin 11, type 2, OB-cadherin (osteoblast); Cadherin-11; OB Cadherin; OB-cadherin; OSF-4; Osteoblast cadherin
Gene Aliases: CAD11; CDH11; CDHOB; OB; OSF-4
UniProt ID: (Human) P55287
Entrez Gene ID: (Human) 1009
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