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Invitrogen
CD80 Monoclonal Antibody (RMMP-1)
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Product Details
MA1-70090
Species Reactivity
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Conjugate
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Product Specific Information
MA1-70090 detects CD80 in mouse samples.
MA1-70090 has been successfully used in flow cytometry procedures.
The MA1-70090 immunogen is mouse B7-1 protein.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Activation B7-1 antigen; B7; B7 protein; CD80; sCD 80; sCD80; soluble CD 80; soluble CD80; T-lymphocyte activation antigen CD80; TS/A-1
Gene Aliases: B7; B71; Cd28l; Cd80; Ly-53; Ly53; MIC17; TSA1
UniProt ID: (Mouse) Q00609
Entrez Gene ID: (Mouse) 12519
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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