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Invitrogen
CD62E/CD62P Monoclonal Antibody (1.2B6)
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Product Details
MA1-80430
Species Reactivity
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Conjugate
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Product Specific Information
MA1-80430 inhibits neutrophil adhesion to E-selectin and to P-selectin.
Non-reducing conditions are recommended for Western blot applications. A suggested positive control is human tonsil. For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human CD62E/CD62P antibody, clone 1.2B6 recognizes the human CD62E and CD62P cell surface antigens.
Target Information
CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1). It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues.CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD62 antigen-like family member E; CD62 antigen-like family member P; CD62E; CD62P; E-selectin; ELAM-1; endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; LECAM-2; LECAM-3; LECAM2; LECAM3; leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-117P20.2; selectin E (endothelial adhesion molecule 1); selectin P (granule membrane protein 140kDa, antigen CD62)
Gene Aliases: CD62; CD62E; CD62P; ELAM; ELAM1; ESEL; GMP140; GMRP; GRMP; LECAM2; LECAM3; PADGEM; PSEL; SELE; SELP
UniProt ID: (Human) P16581, (Pig) P98110, (Human) P16109
Entrez Gene ID: (Human) 6401, (Pig) 397508, (Pig) 397150, (Human) 6403
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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