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Invitrogen
CD321 (F11R) Monoclonal Antibody (H202-106)
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Product Details
MA5-28179
Species Reactivity
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Conjugate
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Product Specific Information
This antibody recognizes murine CD321, also known as junctional adhesion molecule 1 (JAM-1). CD321 is a 274 amino acid, single pass, type I transmembrane glycoprotein, which shares similarities with related proteins JAM-2 and JAM-3. CD321 is a multifunctional protein primarily expressed by platelets, endothelial and epithelial cells.
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: BV11 antigen; CD321; F11 R; F11 receptor/F11R; JAM-1; JAM-A; junction cell adhesion molecule A; junction cell adhesion molecule1; Junctional adhesion molecule 1; Junctional adhesion molecule A
Gene Aliases: 9130004G24; AA638916; ESTM33; F11r; JAM; JAM-1; JAM-A; Jam1; Jcam; Jcam1; Ly106
UniProt ID: (Mouse) O88792
Entrez Gene ID: (Mouse) 16456
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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