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Invitrogen
CD23 Polyclonal Antibody
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FIGURE: 1 / 1
CD23 Antibody (PA5-95951) in WB
Product Details
PA5-95951
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
Immunogen sequence: DTTQSLKQLE ERAARNVSQV SKNLESHHGD QMAQKSQSTQ ISQELEELRA EQQRLKSQDL ELSWNLNGLQ ADLSSFKSQE LNERNEASDL LERLREEVTK LRMELQVSSG FVCNTCPEKW INFQRKCYYF GKGTKQWVHA RYACDDMEGQ LVSIHSPEEQ DFLTKHASHT GSWIGLRNLD LKGEFIWVDG SHVDYSNWAP GEPTSRSQGE DCVMMRGSGR WNDAFCDRKL GAWVCDRLAT CTPPASEGSA ESMGPDSRPD PDGRLPTPSA PLHS; Positive Samples: MCF7; Cellular Location: Cell membrane, Lipid-anchor, Single-pass type II membrane protein
Target Information
CD23 is a 45 kDa glycoprotein that serves as a low-affinity receptor for IgE, playing a crucial role in regulating IgE responses and B cell activation. It is expressed on mature B cells, mantle zone B cells, follicular dendritic cells, and at lower levels on T cells, NK cells, Langerhans cells, and platelets. CD23 expression is upregulated upon B cell activation, and its soluble forms are biologically active, acting as potent mitogenic factors. CD23 is strongly expressed on Epstein-Barr virus (EBV)-transformed B lymphoblasts and is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells. It is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some centroblastic/centrocytic lymphomas. Functionally, CD23 is involved in B cell growth, differentiation, and IgE production. It interacts with CD21 and the alpha subunits of CD11b and CD11c, further influencing immune responses. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia, highlighting its importance in both normal immune function and disease states. This makes CD23 a valuable target for antibody customers interested in B-cell-related research and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: BLAST-2; C-type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD23; CD23 antigen; Fc epsilon receptor II; FC epsilon RII; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc-epsilon-RII; FceRII; Immunoglobulin E-binding factor; immunoglobulin epsilon-chain; Low affinity immunoglobulin epsilon Fc receptor; low-affinity IgE receptor; Lymphocyte IgE receptor
Gene Aliases: BLAST-2; CD23; CD23A; CLEC4J; FCE2; FCER2; Fcer2a; IGEBF; Ly-42
UniProt ID: (Human) P06734, (Mouse) P20693
Entrez Gene ID: (Human) 2208, (Mouse) 14128
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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