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Invitrogen
CD16b Monoclonal Antibody (8F1C10)
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Product Details
MA5-48455
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Target Information
CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms - FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD16-I; CD16b; Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor IIIb; Fc-gamma receptor IIIb (CD 16); Fc-gamma RIII-beta; fc-gamma RIIIb; FcR-10; IgG Fc receptor III-1; Low affinity immunoglobulin gamma Fc region receptor III-B
Gene Aliases: CD16; CD16B; FCG3; FCGR3; FCGR3B; FCR-10; FCRIII; FCRIIIb; IGFR3
UniProt ID: (Human) O75015
Entrez Gene ID: (Human) 2215
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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