Invitrogen

CBS Polyclonal Antibody

Name: CBS Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-120263

View all (26) CBS antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)

CBS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

CBS Antibody (PA5-120263) in IHC (P)

Immunohistochemistry (Immunofluorescence) analysis of CBS in human liver cancer. Samples were incubated with CBS Polyclonal antibody (Product # PA5-120263) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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Immunogen image

Immunogen Image CBS Polyclonal Antibody

Product Details

PA5-120263

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Immunocytochemistry (ICC/IF)

1:50-1:200

ELISA (ELISA)

1 µg/mL

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human CBS (NP_0000621)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.93 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

AB_2913835

Product Specific Information

Positive test controls include: HepG2, 293T, HeLa, MCF7, Mouse liver, Rat liver, Rat kidney. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: MPSETPQAEV GPTGCPHRSG PHSAKGSLEK GSPEDKEAKE PLWIRPDAPS RCTWQLGRPA SESPHHHTAP AKSPKILPDI LKKIGDTPMV RINKIGKKFG LKCELLAKCE FFNAGGSVKD RISLRMIEDA ERDGTLKPGD TIIEPTSGNT GIGLALAAAV RGYRCIIVMP EKMSSEKVDV LRALGAEIVR TPTNARFDSP ESHVGVAWRL KNEIPNSHIL DQYRNASNPL AHYDTTADEI LQQCDGKLDM LVASVGTGGT ITGIARKLKE KCPGCRIIGV DPEGSILAEP EELNQTEQTT YEVEGIGYDF IPTVLDRTVV DKWFKSNDEE AFTFARMLIA QEGLLCGGSA GSTVAVAVKA AQELQEGQRC VVILPDSVRN YMTK

Target Information

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta-thionase; Cystathionine beta-synthase; cystathionine-beta-synthase; Hemoprotein H-450; methylcysteine synthase; Serine sulfhydrase

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Gene Aliases: AI047524; AI303044; CBS; HIP4

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UniProt ID: (Human) P35520, (Rat) P32232, (Mouse) Q91WT9

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Entrez Gene ID: (Human) 875, (Rat) 24250, (Mouse) 12411

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Function(s)

cystathionine beta-synthase activity cysteine synthase activity protein binding oxygen binding enzyme binding heme binding pyridoxal phosphate binding ubiquitin protein ligase binding identical protein binding protein homodimerization activity metal ion binding nitrite reductase (NO-forming) activity carbon monoxide binding nitric oxide binding modified amino acid binding S-adenosyl-L-methionine binding lyase activity

Process(es)

endochondral ossification blood vessel remodeling cysteine biosynthetic process from serine L-serine metabolic process L-serine catabolic process superoxide metabolic process cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration L-cysteine catabolic process cerebellum morphogenesis regulation of cGMP metabolic process response to nutrient levels negative regulation of apoptotic process homocysteine catabolic process regulation of JUN kinase activity homocysteine metabolic process regulation of blood vessel size response to folic acid maternal process involved in female pregnancy cartilage development involved in endochondral bone morphogenesis hydrogen sulfide biosynthetic process cellular response to hypoxia cellular amino acid biosynthetic process DNA protection oxidation-reduction process

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CBS Polyclonal Antibody

CBS Antibody (PA5-120263) in IHC (P)

Product Details

PA5-120263

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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