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Invitrogen
CASC5 Polyclonal Antibody
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FIGURE: 1 / 9
CASC5 Antibody (PA5-114943) in ICC/IF
Product Details
PA5-114943
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Antibody detects endogenous levels of total CASC5.
Target Information
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: AF15q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; Cancer susceptibility candidate gene 5 protein; Cancer susceptibility candidate gene 5 protein homolog; Cancer/testis antigen 29; CT29; kinetochore null 1 homolog; Kinetochore scaffold 1; Kinetochore-null protein 1; microcephaly, primary autosomal recessive 4; Outer kinetochore KNL1 complex subunit KNL1; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; RAD51 homolog
Gene Aliases: 2310043D08Rik; 5730505K17Rik; AF15Q14; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; KNL1; MCPH4; PPP1R55; Rad51; Spc7
UniProt ID: (Mouse) Q66JQ7, (Human) Q8NG31
Entrez Gene ID: (Mouse) 76464, (Rat) 311327, (Human) 57082
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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