Invitrogen

Bcr Polyclonal Antibody

Name: Bcr Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-120023

View all (26) Bcr antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)

Bcr Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

Bcr Antibody (PA5-120023) in IHC (P)

Immunohistochemistry analysis of Bcr in paraffin-embedded human prostate. Samples were incubated with Bcr Polyclonal antibody (Product # PA5-120023) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

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Immunogen image

Immunogen Image Bcr Polyclonal Antibody

Product Details

PA5-120023

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

ELISA (ELISA)

1 µg/mL

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human BCR (NP_004318.3).

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.34 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2913595

Product Specific Information

Positive test controls include: 293T, Jurkat, HeLa, Mouse brain, Rat brain. The target is usually found in the following locations: Cell junction, postsynaptic cell membrane, postsynaptic density, synapse.

Immunogen sequence: MVDPVGFAEA WKAQFPDSEP PRMELRSVGD IEQELERCKA SIRRLEQEVN QERFRMIYLQ TLLAKEKKSY DRQRWGFRRA AQAPDGASEP RASASRPQPA PADGADPPPA EEPEARPDGE GSPGKARPGT ARRPGAAASG ERDDRGPPAS VAALRSNFER IRKGHGQPGA DAEKPFYVNV EFHHERGLVK VNDKEVSDRI SSLGSQAMQM ERKKSQHGAG SSVGDASRPP YRGRSSESSC GVDGDYEDAE LNPRFLKDNL IDANGGSRPP WPPLEYQPYQ SIYVGGMMEG EGKGPLLRSQ

Target Information

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABL; BCR protein; bcr/abl; BCR/FGFR1 chimera protein; breakpoint cluster region; breakpoint cluster region homolog; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; p150; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl

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Gene Aliases: 5133400C09Rik; AI561783; AI853148; ALL; BCR; BCR1; CML; D22S11; D22S662; Kiaa3017; mKIAA3017; PHL

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UniProt ID: (Human) P11274, (Rat) F1LXF1, (Mouse) Q6PAJ1

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Entrez Gene ID: (Human) 613, (Rat) 309696, (Mouse) 110279

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Function(s)

protein serine/threonine kinase activity protein tyrosine kinase activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding ATP binding kinase activity enzyme binding nucleotide binding guanyl-nucleotide exchange factor activity transferase activity

Process(es)

negative regulation of cellular extravasation protein phosphorylation signal transduction brain development peptidyl-tyrosine phosphorylation actin cytoskeleton organization response to lipopolysaccharide regulation of Rho protein signal transduction intracellular signal transduction inner ear morphogenesis regulation of vascular permeability negative regulation of neutrophil degranulation positive regulation of GTPase activity protein autophosphorylation platelet-derived growth factor receptor signaling pathway negative regulation of inflammatory response positive regulation of phagocytosis neuromuscular process controlling balance regulation of small GTPase mediated signal transduction regulation of cell cycle negative regulation of blood vessel remodeling negative regulation of cell migration phosphorylation

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Bcr Polyclonal Antibody

Bcr Antibody (PA5-120023) in IHC (P)

Product Details

PA5-120023

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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