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Invitrogen
Bcr Polyclonal Antibody
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FIGURE: 1 / 3
Bcr Antibody (PA5-104260) in ICC/IF
Product Details
PA5-104260
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Antibody detects endogenous levels of total Bcr.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ABL; BCR protein; bcr/abl; BCR/FGFR1 chimera protein; breakpoint cluster region; breakpoint cluster region homolog; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; p150; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
Gene Aliases: 5133400C09Rik; AI561783; AI853148; ALL; BCR; BCR1; CML; D22S11; D22S662; Kiaa3017; mKIAA3017; PHL
UniProt ID: (Human) P11274, (Mouse) Q6PAJ1
Entrez Gene ID: (Human) 613, (Mouse) 110279
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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