Abnova

BMPR2 Monoclonal Antibody (4A2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
BMPR2 Monoclonal Antibody (4A2)

Product Details

H00000659-M01

Applications
Tested Dilution
Publications

ELISA (ELISA)

3 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

4A2

Immunogen

BMPR2 (NP_001195.2, 939 a.a. approximately 1037 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: NSLDLSATNV LDGSSIQIGE STQDGKSGSG EKIKKRVKTP YSLKRWRPST WVISTESLDC EVNNNGSNRA VHSKSSTAVY LAEGGTATTM VSKDIGMNC

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

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Gene Aliases: BMPR-II; BMPR2; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK

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UniProt ID: (Human) Q13873

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Entrez Gene ID: (Human) 659

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Function(s)
receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity
Process(es)
mesoderm formation maternal placenta development endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway brain development cellular response to starvation anterior/posterior pattern specification positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation regulation of lung blood pressure signal transduction by protein phosphorylation proteoglycan biosynthetic process negative regulation of cell growth positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway regulation of cell proliferation positive regulation of osteoblast differentiation negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway lung alveolus development positive regulation of axon extension involved in axon guidance limb development endochondral bone morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation negative regulation of DNA biosynthetic process
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