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  • BMP4 Antibodies

Fabgennix

BMP4 Polyclonal Antibody, Biotin

View all (29) BMP4 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite BMP4 Polyclonal Antibody, Biotin

BMP4 Polyclonal Antibody, Biotin

Product Details

BMP4-BIOTIN

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 184-197 on rat BMP4 protein, peptide was covalently modified.Sequence:VMKPPAPGHLIC
View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP; BMP-2B; BMP-4; Bone morphogenetic protein; Bone morphogenetic protein 2B; Bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein

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Gene Aliases: Bmp-4; BMP2B; Bmp2b-1; BMP2B1; BMP4; BOMPR4A; Dvr-4; DVR4; MCOPS6; OFC11; ZYME

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UniProt ID: (Human) P12644, (Mouse) P21275

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Entrez Gene ID: (Human) 652, (Mouse) 12159, (Rat) 25296

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Function(s)
cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding co-receptor binding chemoattractant activity protein homodimerization activity BMP receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity skeletal system development ossification angiogenesis ovarian follicle development blood vessel development osteoblast differentiation eye development metanephros development ureteric bud development branching involved in ureteric bud morphogenesis mesoderm formation organ induction kidney development neural tube closure positive regulation of protein phosphorylation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation vasculature development endochondral ossification blood vessel endothelial cell proliferation involved in sprouting angiogenesis chondrocyte differentiation hematopoietic progenitor cell differentiation lymphoid progenitor cell differentiation renal system process BMP signaling pathway involved in heart induction secondary heart field specification type B pancreatic cell development mesenchymal to epithelial transition involved in metanephros morphogenesis common-partner SMAD protein phosphorylation multicellular organism development germ cell development mesodermal cell fate determination heart development positive regulation of cell proliferation negative regulation of cell proliferation post-embryonic development tissue development anterior/posterior axis specification specification of organ position regulation of cell fate commitment regulation of gene expression positive regulation of calcium ion transport into cytosol positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell death positive regulation of neuron projection development telencephalon development dorsal/ventral neural tube patterning telencephalon regionalization pituitary gland development cell differentiation erythrocyte differentiation monocyte differentiation macrophage differentiation lung development embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway forebrain development positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein binding negative regulation of chondrocyte differentiation positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus protein localization to nucleus cellular response to oxidative stress embryonic hindlimb morphogenesis tendon cell differentiation deltoid tuberosity development growth regulation of protein import into nucleus negative regulation of phosphorylation odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis of dentin-containing tooth embryonic digit morphogenesis camera-type eye development positive regulation of apoptotic process negative regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity cell fate commitment regulation of cell differentiation positive regulation of cell differentiation positive regulation of endothelial cell differentiation positive regulation of epidermal cell differentiation negative regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development mesodermal cell differentiation intermediate mesodermal cell differentiation camera-type eye morphogenesis embryonic morphogenesis anatomical structure formation involved in morphogenesis regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation neuron fate commitment embryonic cranial skeleton morphogenesis embryonic skeletal system morphogenesis embryonic skeletal system development negative regulation of oligodendrocyte differentiation smooth muscle tissue development branching morphogenesis of an epithelial tube positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive chemotaxis smooth muscle cell differentiation regulation of smooth muscle cell differentiation cartilage development cardiac muscle cell differentiation positive regulation of cardiac muscle fiber development inner ear receptor cell differentiation lens induction in camera-type eye embryonic skeletal joint morphogenesis bone development cranial suture morphogenesis positive regulation of SMAD protein import into nucleus regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction lung morphogenesis epithelium development bronchus development trachea development trachea formation epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis bud elongation involved in lung branching epithelial cell proliferation involved in lung morphogenesis bud dilation involved in lung branching prostate gland morphogenesis negative regulation of cell death mammary gland formation epithelial-mesenchymal cell signaling negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis regulation of morphogenesis of a branching structure regulation of cartilage development positive regulation of cartilage development positive regulation of branching involved in lung morphogenesis BMP signaling pathway involved in ureter morphogenesis BMP signaling pathway involved in renal system segmentation pulmonary artery endothelial tube morphogenesis negative regulation of thymocyte apoptotic process positive regulation of hepatocyte differentiation regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to dexamethasone stimulus BMP signaling pathway involved in nephric duct formation renal system development negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway glomerular capillary formation negative regulation of glomerular mesangial cell proliferation mesenchymal cell differentiation involved in kidney development ureter epithelial cell differentiation ureter smooth muscle cell differentiation negative regulation of mesenchymal cell proliferation involved in ureter development metanephric collecting duct development positive regulation of kidney development positive regulation of branching involved in ureteric bud morphogenesis negative regulation of branching involved in ureteric bud morphogenesis negative regulation of glomerulus development positive regulation of store-operated calcium channel activity positive regulation of mesenchymal stem cell proliferation negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric comma-shaped body morphogenesis positive regulation of DNA-dependent DNA replication negative regulation of cell proliferation involved in heart morphogenesis positive regulation of endothelial cell apoptotic process mesenchymal cell differentiation involved in renal system development mesonephros development outflow tract septum morphogenesis membranous septum morphogenesis muscular septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac right ventricle morphogenesis apoptotic process involved in endocardial cushion morphogenesis cardiac septum development smoothened signaling pathway response to estradiol response to retinoic acid response to testosterone wound healing tongue morphogenesis response to glucocorticoid anatomical structure regression retina development in camera-type eye cloacal septation lung lobe development coronary vasculature development BMP signaling pathway involved in heart development pharyngeal arch artery morphogenesis cellular response to mechanical stimulus response to nitric oxide cellular response to BMP stimulus glomerular visceral epithelial cell development mesenchymal cell proliferation involved in ureteric bud development mesenchymal cell proliferation involved in ureter development cellular response to thyroid hormone stimulus positive regulation of cell proliferation involved in outflow tract morphogenesis cardiac jelly development negative regulation of extrinsic apoptotic signaling pathway brain development mesoderm development cell proliferation response to mechanical stimulus response to organic cyclic compound
It has to be done as per old AB suggested Products section.
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