Proteintech

BMP-7 Monoclonal Antibody (3E9G7), NeutraKine®

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

69011-1-IG

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1 µg
-

Neutralization (Neu)

200 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3E9G7

Immunogen

NeutraKine BMP-7 fusion protein HZ-1229

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Reconstitute with water to the desired concentration.

Lyophilized antibodies are stable for 1 year from the date of purchase if stored between -20 to -80°C. Upon reconstitution, we recommend that the solution be stored at 4°C (short- term) or at -20 to -80°Cfor long term. Repeated freeze-thaw cycles should be avoided with reconstituted products.

Aliquoting is unnecessary for -20°C storage.

Target Information

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP; BMP-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5

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Gene Aliases: BMP7; OP-1; OP1

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UniProt ID: (Human) P18075

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Entrez Gene ID: (Human) 655

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Function(s)
cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding BMP receptor binding
Process(es)
skeletal system development ossification metanephros development ureteric bud development mesoderm formation mesonephros development epithelial to mesenchymal transition axon guidance embryonic pattern specification negative regulation of striated muscle cell apoptotic process positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation dendrite development embryonic limb morphogenesis positive regulation of bone mineralization BMP signaling pathway epithelial cell differentiation negative regulation of NF-kappaB transcription factor activity response to estradiol response to vitamin D positive regulation of heterotypic cell-cell adhesion protein localization to nucleus growth negative regulation of phosphorylation negative regulation of NF-kappaB import into nucleus odontogenesis of dentin-containing tooth regulation of apoptotic process positive regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity response to peptide hormone negative regulation of neuron differentiation positive regulation of osteoblast differentiation negative regulation of Notch signaling pathway negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic camera-type eye morphogenesis branching morphogenesis of an epithelial tube mesenchymal cell differentiation neuron projection morphogenesis cartilage development embryonic skeletal joint morphogenesis regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction branching involved in salivary gland morphogenesis mesenchyme development negative regulation of cell death negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis monocyte aggregation cellular response to hypoxia cellular response to BMP stimulus negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis negative regulation of glomerular mesangial cell proliferation metanephric mesenchyme morphogenesis nephrogenic mesenchyme morphogenesis metanephric mesenchymal cell proliferation involved in metanephros development positive regulation of dendrite development positive regulation of hyaluranon cable assembly regulation of removal of superoxide radicals
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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