Invitrogen

BDNF Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA1-18372

Applications
Tested Dilution
Publications

Western Blot (WB)

1-10 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1-10 µg/mL
-

Immunocytochemistry (ICC/IF)

1:200
-

ELISA (ELISA)

1-10 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2064216

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Target Information

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Abrineurin; brain derived neurothrophic factor; brain derived neurotrophic factor; Brain-derived neurotrophic factor; H-BDNF; Neurotrophic factor BDNF precursor form; neurotrophin; proBDNF

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Gene Aliases: ANON2; BDNF; BULN2

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UniProt ID: (Human) P23560, (Rat) P23363

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Entrez Gene ID: (Human) 627, (Rat) 24225

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Function(s)
neurotrophin TRKB receptor binding growth factor activity
Process(es)
ureteric bud development behavioral fear response response to hypoxia chronic inflammatory response mitochondrial electron transport, NADH to ubiquinone transmembrane receptor protein tyrosine kinase signaling pathway gamma-aminobutyric acid signaling pathway nervous system development negative regulation of neuroblast proliferation axon guidance axon target recognition learning or memory learning circadian rhythm feeding behavior neuron recognition response to light stimulus response to light intensity response to hormone response to auditory stimulus glutamate secretion response to fluoxetine response to activity dendrite development regulation of metabolic process nerve development neuron differentiation regulation of axon extension response to nutrient levels response to food negative regulation of synaptic transmission, GABAergic positive regulation of peptidyl-serine phosphorylation response to vitamin A response to tumor necrosis factor response to potassium ion mechanoreceptor differentiation response to drug fear response negative regulation of apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron differentiation negative regulation of striated muscle tissue development regulation of retinal cell programmed cell death regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity axon extension inner ear development cognition positive regulation of sequence-specific DNA binding transcription factor activity response to electrical stimulus positive regulation of synapse assembly response to hyperoxia excitatory postsynaptic potential inhibitory postsynaptic potential negative regulation of cell death taste bud development cellular response to tumor necrosis factor cellular response to norepinephrine stimulus response to anesthetic dendrite extension negative regulation of neuron death response to L-glutamate response to nerve growth factor cellular response to nerve growth factor stimulus neuron projection extension positive regulation of glucocorticoid receptor signaling pathway cell-cell signaling synapse assembly brain-derived neurotrophic factor receptor signaling pathway positive regulation of brain-derived neurotrophic factor receptor signaling pathway collateral sprouting positive regulation of collateral sprouting
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