Invitrogen

ApoC3 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
ApoC3 Polyclonal Antibody

Product Details

PA5-112846

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human Apolipoprotein C-III protein (21-99AA)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2867580

Target Information

Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Apo-CIII; apoC-III; Apolipoprotein; apolipoprotein C-3; Apolipoprotein C-III; Apolipoprotein C3; MGC150353

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Gene Aliases: apo-CIII; ApoC-III; APOC3; APOCIII; HALP2

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UniProt ID: (Human) P02656

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Entrez Gene ID: (Human) 345, (Rat) 24207

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Function(s)
phospholipid binding cholesterol binding enzyme regulator activity lipase inhibitor activity high-density lipoprotein particle receptor binding lipid transporter activity
Process(es)
retinoid metabolic process triglyceride metabolic process inflammatory response G-protein coupled receptor signaling pathway positive regulation of triglyceride biosynthetic process negative regulation of triglyceride catabolic process negative regulation of very-low-density lipoprotein particle remodeling negative regulation of very-low-density lipoprotein particle clearance negative regulation of high-density lipoprotein particle clearance negative regulation of low-density lipoprotein particle clearance triglyceride catabolic process regulation of Cdc42 protein signal transduction response to vitamin A cholesterol efflux phospholipid efflux response to triglyceride high-density lipoprotein particle remodeling very-low-density lipoprotein particle assembly chylomicron remnant clearance lipoprotein metabolic process response to drug cholesterol homeostasis lipoprotein transport response to peptide hormone reverse cholesterol transport negative regulation of fatty acid biosynthetic process negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis negative regulation of lipid catabolic process negative regulation of lipoprotein lipase activity negative regulation of cholesterol import triglyceride homeostasis response to fatty acid cellular response to glucose stimulus negative regulation of oxidative phosphorylation response to simvastatin triglyceride mobilization lipid transport response to nutrient cholesterol metabolic process
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