Invitrogen

Angiotensinogen Monoclonal Antibody (03)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Angiotensinogen Monoclonal Antibody (03)

Product Details

MA5-30051

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:250-1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse

Class

Monoclonal

Type

Antibody

Clone

03

Immunogen

Recombinant Human Angiotensinogen/SerpinA8 Protein (Met1-Ala485)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2785840

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Human Angiotensinogen/SerpinA8.

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8

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Gene Aliases: AGT; ANHU; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183

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Function(s)
serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding
Process(es)
regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling angiotensin maturation regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of heart rate regulation of blood vessel size by renin-angiotensin renal system process angiotensin-mediated drinking behavior positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity nitric oxide mediated signal transduction cell-cell signaling female pregnancy aging regulation of blood pressure positive regulation of activation of JAK2 kinase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction response to muscle activity involved in regulation of muscle adaptation negative regulation of angiogenesis regulation of vasoconstriction negative regulation of cell growth positive regulation of cellular protein metabolic process positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity negative regulation of tissue remodeling low-density lipoprotein particle remodeling catenin import into nucleus regulation of renal sodium excretion positive regulation of renal sodium excretion regulation of cell proliferation vasodilation positive regulation of nitric oxide biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of vasodilation fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of neurotrophin TRK receptor signaling pathway stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of branching involved in ureteric bud morphogenesis regulation of extracellular matrix assembly positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway
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