NeoBiotechnologies

Androgen Receptor V7 (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR.V7/9125R)

View all (8) Androgen Receptor (ARv7 Splice Variant) antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Androgen Receptor V7 (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR.V7/9125R)

Product Details

367-RBM19-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

DHTR.V7/9125R

Immunogen

Recombinant fragment (around aa600-920) of human AR protein (AR-V7 specific).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: Breast LNCap cells. Human testis prostate or prostate carcinoma.

Cellular Location: Nucleus.

Target Information

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIS; androgen nuclear receptor variant 2; Androgen receptor; androgen receptor splice variant 4b; AR8; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM

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Gene Aliases: AIS; AR; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM

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UniProt ID: (Human) P10275

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Entrez Gene ID: (Human) 367

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding androgen receptor activity receptor binding steroid binding androgen binding protein binding beta-catenin binding transcription factor binding zinc ion binding enzyme binding transcription regulatory region DNA binding protein dimerization activity ATPase binding
Process(es)
transcription, DNA-templated transcription initiation from RNA polymerase II promoter transport signal transduction cell-cell signaling sex differentiation cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression cell growth androgen receptor signaling pathway intracellular receptor signaling pathway prostate gland development positive regulation of phosphorylation positive regulation of cell differentiation negative regulation of integrin biosynthetic process positive regulation of integrin biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of NF-kappaB transcription factor activity protein oligomerization regulation of establishment of protein localization to plasma membrane negative regulation of extrinsic apoptotic signaling pathway
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