Bioss

Adrenomedullin Polyclonal Antibody

View all (13) Adrenomedullin antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Adrenomedullin Polyclonal Antibody

Product Details

BS-0995R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ADM, amino acids 1-100.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: ADM; AMpreproadrenomedullin; preproadrenomedullin; Pro-adrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM-N20

View more View less

Gene Aliases: ADM; AM; Ap; H39316; PAMP; RATAP

View more View less

UniProt ID: (Human) P35318, (Rat) P43145, (Mouse) P97297

View more View less

Entrez Gene ID: (Human) 133, (Rat) 25026, (Mouse) 11535

View more View less

Function(s)
receptor binding hormone activity protein binding adrenomedullin receptor binding
Process(es)
vasculogenesis response to hypoxia neural tube closure response to yeast regulation of the force of heart contraction G-protein coupled receptor internalization cAMP biosynthetic process progesterone biosynthetic process signal transduction positive regulation of cytosolic calcium ion concentration cell-cell signaling heart development female pregnancy aging blood circulation androgen metabolic process positive regulation of cell proliferation negative regulation of cell proliferation response to cold response to wounding positive regulation of heart rate antibacterial humoral response antifungal humoral response cAMP-mediated signaling positive regulation of cAMP biosynthetic process organ regeneration neuron projection regeneration receptor internalization response to lipopolysaccharide response to insulin odontogenesis of dentin-containing tooth response to starvation positive regulation of apoptotic process negative regulation of vascular permeability positive regulation of angiogenesis negative regulation of vasoconstriction positive regulation of vasodilation hormone secretion developmental growth defense response to Gram-negative bacterium defense response to Gram-positive bacterium response to glucocorticoid branching involved in labyrinthine layer morphogenesis spongiotrophoblast layer development vascular smooth muscle cell development positive regulation of vasculogenesis response to organic substance calcium ion homeostasis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support