Invitrogen

AXIN2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
AXIN2 Polyclonal Antibody

Product Details

PA5-102622

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human AXIN2(Accession Q9Y2T1), corresponding to amino acid residues G41-G91.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2852019

Product Specific Information

Antibody detects endogenous levels of total AXIN2.

Target Information

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Axil; Axin like protein; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582

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Gene Aliases: Axi1; AXIL; AXIN2; Conductin; ODCRCS

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UniProt ID: (Human) Q9Y2T1, (Mouse) O88566, (Rat) O70240

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Entrez Gene ID: (Human) 8313, (Mouse) 12006, (Rat) 29134

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Function(s)
GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding ubiquitin protein ligase binding armadillo repeat domain binding I-SMAD binding
Process(es)
positive regulation of protein phosphorylation intramembranous ossification secondary heart field specification chondrocyte differentiation involved in endochondral bone morphogenesis regulation of transcription, DNA-templated cell proliferation negative regulation of cell proliferation dorsal/ventral axis specification positive regulation of epithelial to mesenchymal transition positive regulation of cell death Wnt signaling pathway bone mineralization regulation of mismatch repair cellular protein localization negative regulation of catenin import into nucleus odontogenesis positive regulation of GTPase activity maintenance of DNA repeat elements negative regulation of osteoblast differentiation mRNA stabilization regulation of chondrocyte development regulation of centromeric sister chromatid cohesion cellular response to organic cyclic compound negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway beta-catenin-TCF complex assembly somitogenesis cell death regulation of Wnt signaling pathway regulation of catenin import into nucleus termination of G-protein coupled receptor signaling pathway positive regulation of protein kinase activity negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
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