Invitrogen

AVP Polyclonal Antibody

1 Reference
View all (6) AVP antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
AVP Polyclonal Antibody

Product Details

PA5-19819

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1-5 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

1:100
-

ELISA (ELISA)

0.002 µg/mL
-
Product Specifications

Species Reactivity

Human, Sheep

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Vasopressin.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11003086

Product Specific Information

Heat mediated antigen retrieval recommended prior to tissue staining.

Not suitable for use with Western Blot.

This antibody is predicted to react with mouse, rat, sheep, cow, cat, dog and pig based on sequence homology.

Target Information

This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: antidiuretic hormone; arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal); AVP-neurophysin II precursor; AVP-NPII; copeptin; neurohypophyseal; prepro-arginine-vasopressin-neurophysin II; prepro-AVP-NP II; Vasopressin; Vasopressin-neurophysin 2-copeptin; vasopressin-neurophysin II-copeptin

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Gene Aliases: ADH; ARVP; AVP; AVP-NPII; AVRP; VP

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UniProt ID: (Human) P01185

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Entrez Gene ID: (Sheep) 443477, (Human) 551

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Function(s)
protein kinase activity signal transducer activity receptor binding neuropeptide hormone activity neurohypophyseal hormone activity V1A vasopressin receptor binding V1B vasopressin receptor binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Process(es)
maternal aggressive behavior positive regulation of systemic arterial blood pressure renal water homeostasis generation of precursor metabolites and energy water transport apoptotic process signal transduction positive regulation of cytosolic calcium ion concentration cell-cell signaling negative regulation of female receptivity grooming behavior locomotory behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of glutamate secretion positive regulation of cell growth positive regulation of cAMP biosynthetic process positive regulation of prostaglandin biosynthetic process positive regulation of cellular pH reduction positive regulation of peptidyl-serine phosphorylation response to testosterone response to nicotine social behavior regulation of renal sodium excretion vasoconstriction hyperosmotic salinity response maternal behavior negative regulation of apoptotic process penile erection negative regulation of cysteine-type endopeptidase activity involved in apoptotic process sodium-independent organic anion transport response to ethanol positive regulation of vasoconstriction negative regulation of transmission of nerve impulse ERK1 and ERK2 cascade protein kinase C signaling negative regulation of release of cytochrome c from mitochondria
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