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OriGene
ATP6V1B2 Monoclonal Antibody (OTI1E11), TrueMAB™
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Product Details
TA505244
Species Reactivity
Host/Isotype
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Type
Clone
Immunogen
Conjugate
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Purification
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Target Information
ATP6V1B2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; Endomembrane proton pump 58 kDa subunit; H+ transporting two-sector ATPase; HO57; testicular secretory protein Li 65; V-ATPase B2 subunit; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform; vacuolar H+-ATPase 56,000 subunit; Vacuolar proton pump subunit B 2
Gene Aliases: ATP6B1B2; ATP6B2; ATP6V1B2; DOOD; HO57; VATB; Vma2; VPP3; ZLS2
UniProt ID: (Human) P21281
Entrez Gene ID: (Human) 526
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