Invitrogen

AP2 gamma Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
AP2 gamma Polyclonal Antibody

Product Details

PA5-116029

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TFAP2C(Accession Q92754), corresponding to amino acid residues V409-K450.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900663

Product Specific Information

Antibody detects endogenous levels of total TFAP2C.

Target Information

The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activating enhancer-binding protein 2 gamma; AP-2.2; AP2-gamma; estrogen receptor factor 1; stimulated by retinoic acid gene 2; Transcription factor AP-2 gamma; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); Transcription factor ERF-1

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Gene Aliases: AA409384; Ap-2.2; AP2-GAMMA; AP2gamma; ERF1; hAP-2g; Stra2; Tcfap2c; TFAP2C; TFAP2G

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UniProt ID: (Human) Q92754, (Mouse) Q61312

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Entrez Gene ID: (Human) 7022, (Mouse) 21420

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein dimerization activity RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell-cell signaling male gonad development regulation of gene expression, epigenetic regulation of cell proliferation positive regulation of transcription from RNA polymerase II promoter trophectodermal cell differentiation hair follicle development keratinocyte development transcription, DNA-templated regulation of transcription, DNA-templated stem cell population maintenance forebrain neuron fate commitment cerebral cortex development cell differentiation germ-line stem cell population maintenance somatic stem cell population maintenance skin development regulation of epidermis development sebaceous gland development dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis epithelial cell proliferation involved in mammary gland duct elongation
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