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Invitrogen
AMID Polyclonal Antibody
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Product Details
PA1-4345
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Product Specific Information
PA1-4345 detects the human PRG3 protein in human samples.
PA1-4345 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~41 kDa protein representing PRG3 in human heart lysate.
The PA1-4345 immunizing peptide corresponds to amino acid residues residues 170-185 of the 41 kDa human PRG3 protein.
Target Information
The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: AMID; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated, 2; Ferroptosis suppressor protein 1; FSP1; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; RP11-367H5.2
Gene Aliases: AIFM2; AMID; PRG3
UniProt ID: (Human) Q9BRQ8
Entrez Gene ID: (Human) 84883
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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