Invitrogen

ALDH1A2 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
ALDH1A2 Polyclonal Antibody

Product Details

PA5-96705

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALDH1A2 (NP_7337971)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.59 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2808507

Product Specific Information

Immunogen sequence: MTSSKIEMPG EVKADPAALM ASLHLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVYNP ATGEQVCEVQ EADKADIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRAVL ATMESLNGGK PFLQAFYVDL QGVIKTFRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC; Positive Samples: SW620, 293T, Mouse liver, Mouse kidney, Mouse testis, Mouse lung, Rat liver; Cellular Location: Cytoplasm

Target Information

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AL1A2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1 family, member A2; aldehyde dehydrogenase 1A2; Aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ALDH1A2; RALDH 2; RALDH(II); ralDH2; Retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2

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Gene Aliases: ALDH1A2; Aldh1a7; AV116159; RALDH(II); Raldh-2; Raldh1; RALDH2; RALDH2-T

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UniProt ID: (Human) O94788, (Mouse) Q62148, (Rat) Q63639

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Entrez Gene ID: (Human) 8854, (Mouse) 19378, (Rat) 116676

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Function(s)
retinal dehydrogenase activity 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity retinal binding oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process(es)
retinoid metabolic process blood vessel development regulation of endothelial cell proliferation heart looping retinoic acid biosynthetic process heart morphogenesis heart development metabolic process positive regulation of cell proliferation negative regulation of cell proliferation determination of bilateral symmetry anterior/posterior pattern specification proximal/distal pattern formation positive regulation of gene expression neural crest cell development morphogenesis of embryonic epithelium neural tube development neuron differentiation lung development embryonic limb morphogenesis forebrain development hindbrain development pancreas development embryonic camera-type eye development response to cytokine embryonic forelimb morphogenesis ureter maturation retinoic acid metabolic process retinal metabolic process 9-cis-retinoic acid biosynthetic process camera-type eye development positive regulation of apoptotic process retinoic acid receptor signaling pathway embryonic digestive tract development cardiac muscle tissue development oxidation-reduction process face development kidney development liver development midgut development pituitary gland development response to estradiol response to vitamin A retinol metabolic process cellular response to retinoic acid vitamin A metabolic process
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