Invitrogen

AKR1C3 Polyclonal Antibody

1 Published Figure
5 References
View all (15) AKR1C3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
AKR1C3 Polyclonal Antibody

Product Details

PA5-28065

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:20,000
View 3 publications 3 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human AKR1C3. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 40% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2545541

Product Specific Information

Recommended positive controls: HepG2, HeLa, AKR1C3shRNA-transfected HeLa, rat liver.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17beta-HSD5; 2-dih; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Aldo-keto reductase family 1 member C18; Aldo-keto reductase family 1 member C3; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); Chlordecone reductase homolog HAKRb; DD-3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; HA1753; HSD1; indanol dehydrogenase; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase

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Gene Aliases: Akr1c18; AKR1C3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS

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UniProt ID: (Human) P42330, (Rat) P51652

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Entrez Gene ID: (Human) 8644, (Rat) 171516

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Function(s)
retinal dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity retinol dehydrogenase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor phenanthrene 9,10-monooxygenase activity dihydrotestosterone 17-beta-dehydrogenase activity prostaglandin H2 endoperoxidase reductase activity prostaglandin D2 11-ketoreductase activity geranylgeranyl reductase activity ketoreductase activity prostaglandin-F synthase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity androsterone dehydrogenase activity testosterone dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity ketosteroid monooxygenase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity indanol dehydrogenase activity delta4-3-oxosteroid 5beta-reductase activity NADP-retinol dehydrogenase activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
Process(es)
protein import into nucleus, translocation retinoid metabolic process prostaglandin metabolic process G-protein coupled receptor signaling pathway response to nutrient steroid metabolic process positive regulation of cell proliferation male gonad development cellular response to starvation positive regulation of cell death farnesol catabolic process cyclooxygenase pathway keratinocyte differentiation cellular response to reactive oxygen species progesterone metabolic process retinol metabolic process retinal metabolic process multicellular organismal macromolecule metabolic process daunorubicin metabolic process doxorubicin metabolic process regulation of retinoic acid receptor signaling pathway positive regulation of protein kinase B signaling oxidation-reduction process testosterone biosynthetic process renal absorption cellular response to cadmium ion cellular response to calcium ion cellular response to prostaglandin stimulus cellular response to corticosteroid stimulus cellular response to jasmonic acid stimulus cellular response to prostaglandin D stimulus negative regulation of retinoic acid biosynthetic process regulation of testosterone biosynthetic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process progesterone catabolic process parturition regulation of steroid biosynthetic process
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