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AKR1C3 Polyclonal Antibody, MaxPab™

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Datasheet
Protocols
Questions & Answers
AKR1C3 Polyclonal Antibody, MaxPab™

Product Details

H00008644-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AKR1C3 (NP_003730.4, 1 a.a. approximately 323 a.a) full-length human protein.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY

Target Information

AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17beta-HSD5; 2-dih; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Aldo-keto reductase family 1 member C3; Chlordecone reductase homolog HAKRb; DD-3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; HA1753; indanol dehydrogenase; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase

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Gene Aliases: AKR1C3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS

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UniProt ID: (Human) P42330

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Entrez Gene ID: (Human) 8644

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Function(s)
retinal dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity retinol dehydrogenase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor phenanthrene 9,10-monooxygenase activity dihydrotestosterone 17-beta-dehydrogenase activity prostaglandin H2 endoperoxidase reductase activity prostaglandin D2 11-ketoreductase activity geranylgeranyl reductase activity ketoreductase activity prostaglandin-F synthase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity androsterone dehydrogenase activity testosterone dehydrogenase (NAD+) activity testosterone 17-beta-dehydrogenase (NADP+) activity ketosteroid monooxygenase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity indanol dehydrogenase activity delta4-3-oxosteroid 5beta-reductase activity NADP-retinol dehydrogenase activity
Process(es)
protein import into nucleus, translocation retinoid metabolic process prostaglandin metabolic process G-protein coupled receptor signaling pathway response to nutrient steroid metabolic process positive regulation of cell proliferation male gonad development cellular response to starvation positive regulation of cell death farnesol catabolic process cyclooxygenase pathway keratinocyte differentiation cellular response to reactive oxygen species progesterone metabolic process retinol metabolic process retinal metabolic process multicellular organismal macromolecule metabolic process daunorubicin metabolic process doxorubicin metabolic process regulation of retinoic acid receptor signaling pathway positive regulation of protein kinase B signaling oxidation-reduction process testosterone biosynthetic process renal absorption cellular response to cadmium ion cellular response to calcium ion cellular response to prostaglandin stimulus cellular response to corticosteroid stimulus cellular response to jasmonic acid stimulus cellular response to prostaglandin D stimulus negative regulation of retinoic acid biosynthetic process regulation of testosterone biosynthetic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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