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Proteintech
AIFM2 Monoclonal Antibody (1A2B2)
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Product Details
68049-1-IG150UL
Species Reactivity
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Target Information
The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: AMID; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; Ferroptosis suppressor protein 1; FSP1; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; RP11-367H5.2
Gene Aliases: 5430437E11Rik; AIFM2; AMID; D730001I10Rik; PRG3
UniProt ID: (Human) Q9BRQ8, (Mouse) Q8BUE4
Entrez Gene ID: (Human) 84883, (Mouse) 71361
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