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ADRA1A Monoclonal Antibody (5G8)

View all (11) alpha-1a Adrenergic Receptor antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
ADRA1A Monoclonal Antibody (5G8)

Product Details

H00000148-M02

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

5G8

Immunogen

ADRA1A (NP_150646, 1 a.a. approximately 27 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MVFLSGNASD SSNCTQPPAP VNISKAI

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADA1; adrenergic, alpha-1A-, receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1C-AR; G protein coupled receptor

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Gene Aliases: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR

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UniProt ID: (Human) P35348

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Entrez Gene ID: (Human) 148

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Function(s)
alpha1-adrenergic receptor activity protein heterodimerization activity
Process(es)
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine positive regulation of systemic arterial blood pressure apoptotic process smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity positive regulation of cytosolic calcium ion concentration cell-cell signaling adult heart development aging negative regulation of cell proliferation response to hormone cell growth positive regulation of synaptic transmission, GABAergic negative regulation of Rho protein signal transduction organ growth intracellular signal transduction response to drug positive regulation of MAPK cascade positive regulation of action potential positive regulation of vasoconstriction positive regulation of smooth muscle contraction micturition calcium ion transport into cytosol positive regulation of cardiac muscle contraction positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of protein kinase C signaling pilomotor reflex
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