Invitrogen

ACVR1B Recombinant Rabbit Monoclonal Antibody (HL1266)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-46980

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1266

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin Receptor Type IB. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938052

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type IB; activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI

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Gene Aliases: 6820432J04; ActR-IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2

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UniProt ID: (Human) P36896, (Mouse) Q61271

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Entrez Gene ID: (Human) 91, (Mouse) 11479

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Function(s)
protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type I activin-activated receptor activity growth factor binding ubiquitin protein ligase binding inhibin binding SMAD binding metal ion binding activin binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
G1/S transition of mitotic cell cycle in utero embryonic development hair follicle development regulation of transcription, DNA-templated protein phosphorylation signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway central nervous system development negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation peptidyl-threonine phosphorylation signal transduction by protein phosphorylation negative regulation of cell growth activin receptor signaling pathway positive regulation of activin receptor signaling pathway nodal signaling pathway positive regulation of erythrocyte differentiation positive regulation of transcription from RNA polymerase II promoter development of primary female sexual characteristics protein autophosphorylation extrinsic apoptotic signaling pathway positive regulation of trophoblast cell migration cell surface receptor signaling pathway mesoderm development embryo development regulation of signal transduction positive regulation of gene expression phosphorylation intracellular signal transduction
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