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Invitrogen
ABH1 Recombinant Rabbit Monoclonal Antibody (JE56-09)
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FIGURE: 1 / 5
ABH1 Antibody (MA5-42511) in IHC (P)
Product Details
MA5-42511
Species Reactivity
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Product Specific Information
Positive Control: Human placenta tissue lysate, MCF-7 cell lysate, Daudi cell lysate, A549 cell lysate, zebrafish tissue lysates, human liver carcinoma tissue, human skin tissue, human small intestine tissue.
Subcellular Location: Mitochondrion, Nucleus.
Target Information
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: alkB, alkylation repair homolog 1; Alkylated DNA repair protein alkB homolog 1; alkylation repair, alkB homolog; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA lyase ABH1; DNA N6-methyl adenine demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase; Nucleic acid dioxygenase ALKBH1
Gene Aliases: ABH; ABH1; alkB; ALKBH; ALKBH1; hABH; si:ch211-133l14.1; zgc:112365
UniProt ID: (Human) Q13686
Entrez Gene ID: (Human) 8846, (Zebrafish) 553720
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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