Invitrogen

ABCA1 Monoclonal Antibody (HJ1)

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers
ABCA1 Monoclonal Antibody (HJ1)

Product Details

MA5-16026

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

HJ1

Immunogen

50 kDa N-terminal extracellular loop of mouse ABCA1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11157018

Product Specific Information

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Target Information

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ABC 1; ABC 1 antibody; ABC Transporter 1; ABC-1; ABC1 antibody; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, sub-family A (ABC1), member 1; CERP antibody; Cholesterol efflux regulatory protein; membrane-bound; Phospholipid-transporting ATPase ABCA1

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Gene Aliases: ABC-1; ABC1; ABCA1; CERP; HDLDT1; TGD

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UniProt ID: (Human) O95477, (Mouse) P41233

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Entrez Gene ID: (Human) 19, (Mouse) 11303, (Rat) 313210

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Function(s)
receptor binding protein binding ATP binding phospholipid binding phospholipid transporter activity anion transmembrane transporter activity cholesterol binding cholesterol transporter activity syntaxin binding small GTPase binding apolipoprotein binding apolipoprotein A-I binding apolipoprotein A-I receptor activity ATPase activity, coupled to transmembrane movement of substances ATPase binding nucleotide binding transporter activity ATPase activity
Process(es)
peptide secretion protein lipidation transport phagocytosis, engulfment lysosome organization G-protein coupled receptor signaling pathway cholesterol metabolic process positive regulation of cholesterol efflux phospholipid transport endosomal transport cholesterol transport positive regulation of cAMP biosynthetic process intracellular cholesterol transport regulation of Cdc42 protein signal transduction cholesterol efflux phospholipid efflux high-density lipoprotein particle assembly apolipoprotein A-I-mediated signaling pathway lipoprotein metabolic process lipoprotein biosynthetic process cholesterol homeostasis reverse cholesterol transport phospholipid translocation interleukin-1 beta secretion transmembrane transport phospholipid homeostasis response to high density lipoprotein particle platelet dense granule organization cellular response to lipopolysaccharide cellular response to retinoic acid anion transmembrane transport response to nutrient ion transmembrane transport response to laminar fluid shear stress response to drug response to low-density lipoprotein particle cellular response to cholesterol negative regulation of macrophage derived foam cell differentiation negative regulation of cholesterol storage
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