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Invitrogen
A2M Polyclonal Antibody
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FIGURE: 1 / 1
A2M Antibody (PA5-120391) in WB
Product Details
PA5-120391
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Storage buffer
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RRID
Product Specific Information
Positive test controls include: SH-SY5Y, Mouse kidney, Mouse ovary, Rat spinal cord. The target is usually found in the following locations: Secreted.
Immunogen sequence: ALAGNQDKRK EVLKSLNEEA VKKDNSVHWE RPQKPKAPVG HFYEPQAPSA EVEMTSYVLL AYLTAQPAPT SEDLTSATNI VKWITKQQNA QGGFSSTQDT VVALHALSKY GAATFTRTGK AAQVTIQSSG TFSSKFQVDN NNRLLLQQVS LPELPGEYSM KVTGEGCVYL QTSLKYNILP EKEEFPFALG VQTLPQTCDE PKAHTSFQIS LSVSYTGSRS ASNMAIVDVK MVSGFIPLKP TVKMLERSNH VSRTEVSSNH VLIYLDKVSN QTLSLFFTVL QDVPVRDLKP AIVKVYDYYE TDEFAIAEYN APCSKDLGNA
Target Information
Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregnancy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer's disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: A2mp; Alpha 2 M; Alpha-2-M; Alpha-2-M (A2M); Alpha-2-macroglobulin; Alpha-2-macroglobulin-P; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; DKFZp779B086; S863 7
Gene Aliases: A2M; A2m1; A2maa; A2MAC1; A2MD; A2mp; CPAMD5; FWP007; Mam; S863-7
UniProt ID: (Human) P01023, (Mouse) Q6GQT1, (Rat) P06238
Entrez Gene ID: (Human) 2, (Mouse) 232345, (Rat) 24153
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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