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Invitrogen
A-Raf Recombinant Rabbit Monoclonal Antibody (4U9L7)
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FIGURE: 1 / 2
A-Raf Antibody (MA5-42891) in IHC (P)
Product Details
MA5-42891
Species Reactivity
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Product Specific Information
Positive test controls include: HeLa, MCF7.
Immunogen sequence: RQHEAPSNRP LNELLTPQGP SPRTQHCDPE HFPFPAPANA PLQRIRSTST PNVHMVSTTA PMDSNLIQLT GQSFSTDAAG SRGGSDGTPR GSPSPASVSS GRKSPHSKSP AEQRERKSLA DDKKK
Target Information
Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. A-Raf, a second member of the Raf gene family of serine/ threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of A-Raf is found at highest levels in urogenital tissues and kidney and at lowest level in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: A-Raf proto-oncogene serine/threonine-protein kinase; A-raf-1; Oncogene ARAF1; Proto-oncogene A-Raf; Proto-oncogene A-Raf-1; Proto-oncogene Pks; raf a; Ras-binding protein DA-Raf; RP1-230G1.1; Serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf murine sarcoma 3611 viral oncogene-like protein
Gene Aliases: A-RAF; ARAF; ARAF1; PKS; PKS2; RAFA1
UniProt ID: (Human) P10398
Entrez Gene ID: (Human) 369
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